Oestrous Cycle and Uterine Histology of Aged Albino Wistar Rats After Combined Therapy of Leaf Extracts of L. lanceolata and A. cordifolia

Document Type : Original Article

Authors

1 Department of Anatomical Sciences, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria

2 Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria

Abstract

Peri-menopause, menopause and associated symptoms can be a source of distress to women, particularly as it heralds the end of the reproductive life of a woman.  Oestrous cycle disorders frequently affect the quality of life of peri-menopausal women and can be indicators of serious underlying problems. This study examined the changes in the oestrous cycle and uterine histology of aged albino wistar rats. Twenty-five female albino wistar ratsdivided into Groups A, C, D, and E consisting of aged irregularly cycling rats and Group B consisting of young regularly cycling rats were used for this study. Extract administration of L. lanceolata and A. cordifolia to the treated groups was for 21 days and cycling of the rats was carried out during this period. The animals were sacrificed on the 22nd day (pro-oestrus phase) and the uterus was dissected out for tissue processing. The findings in this study showed oestrous cycle was regularized in most of the rats in all the treatment groups. The features of the histology of the uterus were consistent with normal expectations in the pro-oestrus phase of the cycle. In conclusion, treatment with L. lanceolata and A. cordifolia restores normal cyclicity in aged irregularly cycling rats, therefore it may be used in the management of menstrual cycle abnormalities, and sub-fertility associated with the peri-menopause, and other unpleasant symptoms associated with the perimenopause and menopause.  

Keywords

Files

Share

How to cite

Statistics