Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids

Document Type : Original Article

Authors

1 Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan

2 Department of Biology Government college Sillanwali, District Sargodha, Pakistan

Abstract

The aim of present project was to determine the harmful effects of CdCl2 on epididymis of adult mice (Mus musculus). Histopathological changes in epididymis of mice treated with 50ppm of CdCl2 were studied in this research work. Moreover, remedial effects of Jambul fruit extract were also studied. Study was conducted on 30 male albino mice divided into three groups (n=10) as follows; {(a) Control (C); (untreated); (b) CdCl2 {50ppm CdCl2 as drinking water (15 days) and for natural recovery CdCl2 free water (7days); (c) CdCl2+Jambul extract (CdCl2+J) 50ppm CdCl2 in drinking water for 15 days followed by 0.2mLJambul extract (7days)}. All animals were dissected on day 21st for surgical removal of epididymis. The results revealed that mean tubular cross-sectional area of caput, corpus and cauda epididymis was significantly increased in CdCl2 treated group compared to Control and Cd+J treated groups. A single peritoneal administration of soluble cadmium causes an acute hemorrhagic reaction in proximal end of caput epididymis. The lining epithelium of the proximal caput was atrophied, tubules were dilated and spermatozoa within the lumen were disintegrated.

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