Age related changes of vermiform appendix (Histomorphometric study)

Document Type : Original Article

Authors

1 University of Anbar, College of Pharmacy. Clinical and Laboratory Science department

2 University of Tikrit, College of medicine. Anatomy department

Abstract

Background: Many researches and studies were performed to investigate many aspects of the vermiform appendix. Many variations were observed at the different regions, among that, the focus was made on the lymphoid number and diameter, wall thickness, and luminal diameter.
Objective: The aim of this work was to a finding of histomorphometery features of the adult vermiform appendix for different sex and age groups.
Materials & methods: Fifty cadavers were included and divided into five age groups; A(20-29), B(30-39), C(40-49), D(50-59), and E(60-70)years. Ten cadavers were included for each age group. The inclusion criteria of the cadavers were brain stroke, built injuries, sudden death, car accident, and angina pectorals. The exclusion was with gangrenous, grossly inflammation and perforated appendices cadavers. Total length was measured from the base to the tip, as well as the diameter using a digital vernier caliper. Histological slides were made using H&E for counting the number and diameter of lymphoid follicles.
Results: Wall thickness and luminal diameter decreased from the base towards the tip. Luminal diameter decreased from the base towards the tip. Luminal diameters increased with age group increase. The number of follicles decreased from the base towards the tip and decreased also with increasing age groups. The number and diameter of lymphoid follicles are more in males than in females. Wall thickness decreased with increasing age groups.
Conclusion: Histomorphometric changes of the vermiform appendix were obvious along with the Wall thickness; Number and diameter of lymphoid follicles. Male and females have shown clear differences with increasing age groups.

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