Elevated Cellular-microparticles Expressing Platelets and Endothelial Markers in Cardio-vascular Ischemic Infarction (A Possible New Challenge for Early Diagnosis)

Document Type : Original Article

Authors

1 Department of Zoology .Faculty of Science .Fayoum University El-Fayoum Egypt

2 Fayoum University Hospital. Fayoum University El-Fayoum Egypt

Abstract

Cellular microparticles are plasma membrane vesicles of 0.05). A cutoff value for the expression of CD61p as a marker of thrombotic MI was suggested to be (58.70) revealed (70%) sensitivity and (85%) specificity and as regards CD 62E/61, taking (22.25) as a cut-off point revealed (60%) sensitivity and (95%) specificity using ROC curve statistical method. In conclusions, the antithrombotic properties of low dose antiplatelet or anticoagulant therapy are not strong enough to suppress shedding of the microparticles. A cut off value for expression of CD61 and coexpression CD 62E/61 in MI patients can contribute to the clinical applications as using MP assay in early diagnosis of thrombotic propensity, monitoring of anticoagulant therapy, and detection the risk of ischemic heart diseases in high-risk patients.

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